Preheat your grill to medium-high heat.
In a large mixing bowl, combine the ground beef, shredded cheddar cheese, cream cheese, chopped jalapeño peppers, minced garlic, onion powder, smoked paprika, salt, and pepper. Use your hands to mix until all ingredients are evenly incorporated.
Divide the beef mixture into 4 equal portions and shape each portion into a burger patty, making sure to press the center slightly thinner than the edges to prevent bulging during cooking.
Place the burger patties on the preheated grill and cook for 4-5 minutes on each side, or until the internal temperature reaches your desired level of doneness (160°F/71°C for medium).
While the burgers are cooking, toast the burger buns on the grill until lightly golden brown.
Once the burgers are cooked to your liking, remove them from the grill and let them rest for a few minutes.
Assemble your burgers by placing each patty on a toasted bun and adding your favorite toppings such as lettuce, tomato slices, red onion slices, avocado slices, mayonnaise, ketchup, and mustard.
Serve the jalapeño cheddar cheese beef burgers immediately and enjoy!